The many genetic complementation groups of DNA excision‐repair defective mammalian cells indicate the considerable complexity of the excision repair process. The cloning of several repair genes is taking the field a step closer to mechanistic studies of the actions and interactions of repair proteins. Early biochemical studies of mammalian DNA repair in vitro are now at hand. Repair synthesis in damaged DNA can be monitored by following the incorporation of radiolabelled nucleotides. Synthesis is carried out by mammalian cell extracts and (...) is defective in extracts from cell lines derived from individuals with the excisionrepair disorder xeroderma pigmentosum. Biochemical complementation of the defective extracts can be used to purify repair proteins. Repair of damage caused by agents including ultraviolet irradiation, psoralens, and platinating compounds has been observed. Neutralising antibodies against the human single‐stranded DNA binding protein (HSSB) have demonstrated a requirement for this protein in DNA excision repair as well as in DNA replication. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:“Garrulus sum et loquax et expedire nescio. Diu te tenui in istis, sed de cetero procedam.” These are the words of Richard Rufus of Cornwall, a thirteenth-century Scholastic and lecturer at the Universities of Paris and Oxford. Rufus is apologizing to his readers: “I am garrulous and loquacious, and I don’t know how to be efficient. I have detained you with these things a long while, but let (...) me now proceed to another topic.” This apology introduces the third part of the Speculum animae, a preliminary modern edition of which we publish here. In this short treatise, Rufus presents a unique Aristotelian theory of perception, describes what is and is not intelligible, and finally proves to his own satisfaction the immortality of the rational soul. To us this would hardly seem the place to apologize for being long-winded; indeed, we might wonder how Rufus could accomplish such an ambitious task in such a short treatise. We would certainly not accuse him of excessive verbosity. But Rufus was a man of exceptional humility, who once referred to himself as the least of the lesser thinkers of his time.1Despite Rufus’s humility, he was no minor figure in the development of Scholastic philosophy. A teacher at the Universities of Paris and Oxford ,2 he is the author of the earliest known, surviving lectures on several of Aristotle’s major texts, including the Metaphysics, the Physics, De generatione et corruptione, and De anima3 . In fact, Rufus was one of the very first lecturers to teach the libri naturales at Paris after a ban on such instruction was effectively lifted in 1231 A.D. His works were influential not only among his contemporaries, but also among later authors, particularly John Duns Scotus. Roger Bacon, though a harsh critic of Rufus, acknowledged Rufus’s influence and fame decades after his death, albeit among what Bacon termed the “vulgar multitude.”4The Speculum animae is one of Rufus’s later works. He begins the treatise by posing the following question: “In what way is the soul all things?” This refers, of course, to a familiar doctrine Aristotle establishes in the De anima—that the soul is, in some way, all things —and Rufus is here seeking to clarify it. But this is, in fact, only the first of five questions addressed in the Speculum. The five questions Rufus posits and answers in this treatise are, in order:1. In what manner is the soul all things?2. In what manner do a sensible and the sense, or an intelligible and the possible intellect, become one?3. What is predicated and of what is it predicated?4. What is intelligible?5. What is the cause of the immortality of the soul?In this short work, therefore, Rufus addresses apparently diverse topics including perception, understanding, logic, and the nature of the soul. But, in fact, the Speculum is principally a summary of Rufus’s theory of human perception and understanding. Like other medieval theories of perception and understanding, Rufus’s theory centers around the notion of species, a kind of form that is received in the soul when a person senses something or grasps something intellectually.5 In this, and in other aspects of the theory, Rufus was heavily dependent on Aristotle and St. Augustine. Rufus was working in a philosophical tradition based on Aristotle’s categories that had been accepted for centuries in the West. But in his lifetime, the Aristotelian corpus was enlarged to include Aristotle’s psychology and more generally his natural philosophy and metaphysics, together with the commentaries of Averroës . As is well known, this philosophical tradition was respected and continued not just by Rufus but by many authors after his time.So what makes Rufus’s theory.. (shrink)

이 책자는 형식 논리의 일종인 양상논리에 입문하고 싶으신 분들을 위한 짧은 교재입니다. “양상논리 맛보기” 라는 말마따나, 이 책자는 양상논리에 관심은 있지만 아직 본격적으로 공부를 시작하진 않은 분들께서 ‘맛보기’를 하기에 적합한 안내 책자입니다. 아무쪼록 이 책자가 양상논리를 공부해나가시는데 유용한 첫 발판이 될 수 있기를 바랍니다. / This booklet is a Korean adaptation and translation of Part VIII of forall x: Calgary (Fall 2021 edition), which is intended to be introductory material for modal logic. The original text is based on Robert Trueman's (...) A Modal Logic Primer, which is revised and expanded by Richard Zach and Aaron Thomas-Bolduc in forall x: Calgary. (forall x: Calgary is based on forall x: Cambridge by Tim Button, which is in turn based on forall x by P. D. Magnus, and also includes material from forall x: Lorain County Remix by Cathal Woods and J. Robert Loftis.) This booklet is licensed under a Creative Commons Attribution 4.0 license. (shrink)

Three puzzles about self-deception make this mental phenomenon an intriguing explanatory target. The first relates to how to define it without paradox; the second is about how to make sense of self-deception in light of the interpretive view of the mental that has become widespread in philosophy; and the third concerns why it exists at all. In this paper I address the first and third puzzles. First, I define self-deception. Second, I criticize Robert Trivers’ attempt to use adaptionist evolutionary psychology (...) to solve the third puzzle (existence). Third, I sketch a theory to replace that of Trivers. Self-deception is not an adaptation, but a spandrel in the sense that Gould and Lewontin give the term: a byproduct of other features of human (cognitive) architecture.Self-deception is so undeniable a fact of human life that if anyone tried to deny its existence, the proper response would be to accuse this person of it. (Allen Wood, Citation 1988 ). (shrink)

By a thorough study of the Posterior Analytics and related Aristotelian texts, Richard McKirahan reconstructs Aristotle's theory of episteme--science. The Posterior Analytics contains the first extensive treatment of the nature and structure of science in the history of philosophy, and McKirahan's aim is to interpret it sympathetically, following the lead of the text, rather than imposing contemporary frameworks on it. In addition to treating the theory as a whole, the author uses textual and philological as well as philosophical material (...) to interpret many important but difficult individual passages. A number of issues left obscure by the Aristotelian material are settled by reference to Euclid's geometrical practice in the Elements. To justify this use of Euclid, McKirahan makes a comparative analysis of fundamental features of Euclidian geometry with the corresponding elements of Aristotle's theory. Emerging from that discussion is a more precise and more complex picture of the relation between Aristotle's theory and Greek mathematics--a picture of mutual, rather than one-way, dependence. Originally published in 1992. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905. (shrink)

A number of studies in the apparent motion literature were examined using the cognitive penetrability criterion to determine the extent to which beliefs affect the perception of apparent motion. It was found that the interaction between the perceptual processes mediating apparent motion and higher order processes appears to be limited. In addition, perceptual and inferential beliefs appear to have different effects on perceived motion optimality and direction. Our findings suggest that the system underlying apparent motion perception has more than one (...) stage and is informationally encapsulated from cognitive factors. (shrink)

The purpose of this paper is to communicate some developments in what we call the new logic. In a nutshell the new logic is a model of the behaviour of a logical agent. By these lights, logical theory has two principal tasks. The first is an account of what a logical agent is. The second is a description of how this behaviour is to be modelled. Before getting on with these tasks we offer a disclaimer and a warning. The disclaimer (...) is that although the new logic is significantly different from it, we have no inclination to see the new logic as a rival of mathematical logic. We do not advocate the displacement of, e.g. model theory, but rather its supplementation or adaptation. The warning is that, whereas mathematical logic must eschew psychologism, the new logic cannot do without it. The fuller story of the new logic must eschew psychologism, the new logic cannot do without it. The fuller story of the new logic is part of our book, The Reach of Abduction, scheduled to appear in 2001 or early 2002. (shrink)

. Moral systems are described as systems of indirect reciprocity, existing because of histories of conflicts of interest and arising as outcomes of the complexity of social interactions in groups of long‐lived individuals with varying conflicts and confluences of interest and indefinitely iterated social interactions. Although morality is commonly defined as involving justice for all people, or consistency in the social treatment of all humans, it may have arisen for immoral reasons, as a force leading to cohesiveness within human groups (...) but specifically excluding and directed against other human groups with different interests. (shrink)

Stone-walling dialogues are exercises in structured non-cooperation. It is true that dialogue participants need to cooperate with one another and in ways sufficient to make possible the very dialogue they are now having. Beyond that there is room for non-cooperation on a scale that gives great offence to what we call the Goody Two-Shoes Model of argument. In this paper, we argue that non-cooperation dialogues have perfectly legitimate objectives and that in relation to those objectives they need not be considered (...) at all subpar to conversations that brim with sunny amity.Two categories of stone-walling non-cooperation dialogues are here examined. They are called MindClosed and NoEngage. They are exemplified by the following cases:1. Hostile Police Interrogation2. Judicial Cross-Examination3. Department Store Complaints Management4. Lakatosian Science5. Gödel's First Incompleteness Proof. (shrink)

Since Freud, clinicians have understood that disturbing memories contribute to psychopathology and that new emotional experiences contribute to therapeutic change. Yet, controversy remains about what is truly essential to bring about psychotherapeutic change. Mounting evidence from empirical studies suggests that emotional arousal is a key ingredient in therapeutic change in many modalities. In addition, memory seems to play an important role but there is a lack of consensus on the role of understanding what happened in the past in bringing about (...) therapeutic change. The core idea of this paper is that therapeutic change in a variety of modalities, including behavioral therapy, cognitive-behavioral therapy, emotion-focused therapy, and psychodynamic psychotherapy, results from the updating of prior emotional memories through a process of reconsolidation that incorporates new emotional experiences. We present an integrated memory model with three interactive components – autobiographical (event) memories, semantic structures, and emotional responses – supported by emerging evidence from cognitive neuroscience on implicit and explicit emotion, implicit and explicit memory, emotion-memory interactions, memory reconsolidation, and the relationship between autobiographical and semantic memory. We propose that the essential ingredients of therapeutic change include: (1) reactivating old memories; (2) engaging in new emotional experiences that are incorporated into these reactivated memories via the process of reconsolidation; and (3) reinforcing the integrated memory structure by practicing a new way of behaving and experiencing the world in a variety of contexts. The implications of this new, neurobiologically grounded synthesis for research, clinical practice, and teaching are discussed. (shrink)

Since its publication in 1994, Richard McKirahan's _Philosophy Before Socrates_ has become the standard sourcebook in Presocratic philosophy. It provides a wide survey of Greek science, metaphysics, and moral and political philosophy, from their roots in myth to the philosophers and Sophists of the fifth century. A comprehensive selection of fragments and testimonia, translated by the author, is presented in the context of a thorough and accessible discussion. An introductory chapter deals with the sources of Presocratic and Sophistic texts (...) and the special problems of interpretation they present. In its second edition, this work has been updated and expanded to reflect important new discoveries and the most recent scholarship. Changes and additions have been made throughout, the most significant of which are found in the chapters on the Pythagoreans, Parmenides, Zeno, Anaxagoras, and Empedocles, and the new chapter on Philolaus. The translations of some passages have been revised, as have some interpretations and discussions. A new Appendix provides translations of three Hippocratic writings and the Derveni papyrus. (shrink)

This book is a succinct introduction to the orienting of attention.

The so-called “mind-brain” problem affords the greatest opportunity for the cooperation of philosophy and science in the advancement of knowledge. In this paper we will outline pertinent facts already learned about the human mind from neurological disciplines, and, using some hypotheses from outstanding workers in neurobiology, we will relate this material to some important philosophical problems. Our proposal is to examine these problems in the light of knowledge gathered from the scientific disciplines, and we hope to demonstrate how this method (...) may eventually clarify some of the confusion and suggest certain solutions. (shrink)

Does media coverage of politics undermine democratic deliberation? By covering the “horse race” instead of the issues, the media encourage people to believe that politicians place self‐interest above the public interest. The media also affect which issues people consider important, and negative advertisements discourage political participation. People learn from the media only because they know so little about politics. Were democracy deliberative, these media effects would undermine it. But democracy is not a deliberation but a contest that relies on the (...) ability of the media to shape public opinion. The evidence for media effects is strong, but the media cannot be undermining a form of democracy that does not and cannot exist, and they do sustain the form that does. (shrink)

In a previous essay, Richard Ryder argued against Utilitarianism's aggregation of pains across individuals. He continues this argument and rebuts several criticisms of his moral theory of painism. Painism not only rejects the aggregation of pains across individuals, it also questions the trade-off of pains against pleasures.

In this article, I argue that, in showing inconsistency of beliefs, Socratic elenchus is showing incompatibility of the desires those beliefs express. This thesis explains Socrates’ claim that, in refuting Callicles, he is also restraining his desires. The beliefs in question are about the best kind of life to lead; such beliefs express the second order desire to lead a life in which certain sorts of first order desires are satisfied. Socrates’ elenchus shows that Callicles is caught between two incompatible (...) second order desires: a desire to lead of life of enormous pleasure and a desire to lead a life in which his love of honor is satisfied. Socrates does not succeed with Callicles because the way out of this dilemma depends on a type of desire not found in the moral psychology of the Gorgias, i.e., a desire whose satisfaction is pleasure unmixed with pain, described in Republic 583c-585e and Philebus 50e-52b. (shrink)

Richard Ryder, one of the founding fathers of the modern animal rights movement, here explains his latest thinking about morality.

The relations between different areas of knowledge have been a subject of interest to philosophers as well as to scientists and mathematicians from antiquity. While recent work in this direction has been largely concerned with the question whether one branch of knowledge can be reduced to another , the questions which exercised the Greek philosophers on these matters have a different starting point. Taking for granted that there are a number of distinct areas of knowledge, they proceeded to consider a (...) variety of relations which they observed to hold among the sciences as they knew them; the question of the priority of one science to another is a recurrent theme. In fact, three sorts of orderings were noticed, and the associated conceptions of priority are interesting. Only one of them is the concern of the present paper, though, and I shall briefly describe the remaining two only for purposes of contrast. (shrink)

In Republic ix, Socrates begins his argument that deceptive pleasure causes insatiable desire by citing the error that cessation of pain is the greatest pleasure. Some interpret this error as an illusion, experiencing pleasure when there is no pleasure; but illusion cannot explain insatiable desire. Our interpretation explains insatiable desire—and Socrates’ restatement of wisdom and justice to include pleasures, which links the knowledge of unchanging reality with these virtues.

This book, a member of the Series in Affective Science, is a unique interdisciplinary sequence of articles on the cognitive neuroscience of emotion by some of ...

This first volume in the Rutgers Series on Self and Social Identity presents a sophisticated and detailed analysis of some of the most fundamental issues facing scholars interested in studying self and identity. Chapters written by a world-class set of social scientists, from the fields of psychology, sociology, and anthropology, represent the diverse issues, perspectives, and controversies inherent in the recent wave of interest in the self, and suggest productive avenues of analysis and empirical research.